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Scientist II, Potency and Impurities

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Job Id JOB ID-10175 Standort Redmond, Washington Date posted 02/01/2024 Category Research & Development

Just- Evotec Biologics is seeking a motivated and creative Scientist II who desires a significant opportunity to improve worldwide access to biotherapeutics. The candidate will join a fast-paced, collaborative, and multidisciplinary team to develop and execute methods for the functional and potency assessment and impurity monitoring of biotherapeutics.  As a key member of the analytical development group, the successful candidate will have significant experience in immunoassay and liquid handler method development and qualification/validation, as well as strong experimental design and data analysis skills. Previous experience in late-stage and first-in-human (FIH) development and experience authoring regulatory documents is desirable. This person should have significant experience and understanding in ELISAs, Octet/BLI, AlphaLISA, liquid handlers (such as Tecan or Hamilton) and/or Biacore/SPR methods. The ideal candidate has strong written and verbal communication skill, multitasks effectively, works well independently and in teams, and is excited about ways to improve technology.

Responsibilities:

  • Characterization of early and late stage biotherapeutics using diverse biological assay formats
  • Lead and implement method development, DOE robustness, and qualification activities
  • Technology transfer to Just- Evotec’s Quality Control laboratory
  • Participation in process development team(s), including potential for acting as functional lead
  • Technology development to improve throughput and efficiency
  • Present data to a wide range of audiences, including internal technical development teams, clients, industry conferences, and peer-reviewed journals
  • Develop immunoassay and kinetic assay (BLI/Octet, Biacore/SPR) efforts for the group
  • Develop methods utilizing liquid handlers (e.g. Hamilton, Tecan)

Required Qualifications:

  • PhD with 2+ years relevant direct industry experience, MS with 4+ years’ industry experience, or BS with 8+ years’ experience, with degrees in Biochemistry, Molecular and Cellular Biology, Chemical Engineering, Bioengineering, Chemistry or related field
  • Experience developing analytical methods in a CMC or GMP-like industry setting
  • General understanding of ICH/USP guidelines on analytical, kinetic, and potency assay development and validation
  • Experience in the development, DOE robustness, and qualification and/or validation of release potency
  • Strong technical understanding of link between MOA and analytical method development
  • Experience in areas of technology development pertinent to potency assay development, including but not limited to assay automation and miniaturization via liquid handler
  • Experience developing and applying biological characterization methods (SPR/BLI or other protein binding kinetic assays, immunoassays, homogeneous assay formats such as AlphaLISA)
  • Strong oral and written communication skills
  • Desire to work in a fast, collaborative, and team-oriented environment

Preferred Qualifications:

  • Experience utilizing industry-standard analysis software (e.g. SoftMax Pro, JMP)
  • Development of liquid-handling automation applications
  • Development of kinetic potency assays (e.g. BLI/SPR)
  • Experience with early & late stage regulatory filings 
  • Experience in technology transfer
  • Experience participating in CMC teams

The base pay range for this position at commencement of employment is expected to be $75,000 to $108,000;  Base salary offered may vary depending on individual’s skills, experience and competitive market value. Additional total rewards include discretionary annual bonus, comprehensive benefits to include Medical, Dental and Vision, short-term and long-term disability, company paid basic life insurance, 401k company match, flexible work, generous paid time off and paid holiday, wellness and transportation benefits

Evotec (US) Inc. is an Equal Opportunity Employer.  All qualified applicants will receive consideration for employment without regard to race, gender, age, disability, genetic information, gender expression, gender identity, national origin, religion, sexual orientation, or veteran status.

What makes us unique 

  • rocket

    Our business model

    With Evotec’s Action Plan 2025 “The data-driven R&D Autobahn to Cures”, our goal is to stay competitive in the ever evolving life science industry. Together for medicines that matter.

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  • builb

    Our expertise

    Togehter, we are creators and turn imaginations into cures. With Evotec, a smart idea can unfold and mature, with the help of our high expertises and cutting-edge technologies.

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  • group

    Our team

    Our collaborative and trustful work environment enables solution-oriented discussions among colleagues. We inspire each other to great aspirations and know that, together, we’ll go further.

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Success Profile

Cultural fit and soft skills are important factors for success. Check out the traits we’re looking for:

Success Profile

Cultural fit and soft skills are important factors for success. Check out the traits we’re looking for:

  • Curiosity
  • Resilient
  • Creative mindset
  • Teamplayer
  • Forward-thinking
  • Adaptable

Introduction:

Our Data-driven Autobahn Towards Cures