Principal Scientist - ADME

About Us: this is who we are

At Cyprotex US, an Evotec company, we believe that curiosity is the spark that drives innovation and success. As a forward-thinking team, we thrive on challenging the status quo, learning from each other, and pushing the boundaries of what’s possible. We're on a mission to create a place where curiosity isn't just encouraged—it’s celebrated. Are you someone who asks questions, seeks answers, and isn't afraid to go deeper? #BeCureious with us and see where your curiosity can take you!

Cyprotex US specializes in ADME-Tox and Biosciences including both in vitro (laboratory experiments) and in silico (computer modelling) approaches. Cyprotex was founded in 1999. The Company serves the Pharmaceutical and Biotech, Cosmetics/Personal Care and Chemicals Industries as well as academia and not-for-profit organizations. Over 1700 organizations trust Cyprotex for their ADME-Tox and Bioscience research needs.

The Role: Your challenge …in our journey

We’re looking for a passionate and curious Principal Scientist to join our team. If you’re excited by new challenges, solving complex problems, and learning every step of the way, you might just be the perfect fit. In this role, you’ll have the opportunity to drive impactful projects, collaborate with bright minds, and explore uncharted territories.

As a Principal Scientist at Cyprotex, you'll have the freedom to ask the hard questions, think outside the box, and find creative solutions that push us forward. It’s a role where your curiosity will fuel both your personal growth and the success of the team.

What You'll Do:

As a Principal Scientist, you will be working closely with other members of the team managing both  client and R&D projects, ensuring these are performed to a high standard and within scheduled time-frames.  In addition, as a visible leader in the group, utilizing excellent communication, organizational and technical skills, you will support the training and development of staff, improving the team’s knowledge and processes.  You will work with the VP to create and cascade the short and medium term vision and strategy for the team. 

Scientific

• Be a senior point of contact within the group for operational and scientific support across all ADME assays (troubleshooting, data analysis and interpretation). 

• Identify opportunities for and lead cross functional collaboration. 

• Design and perform novel ADME assays  

• Conduct in vitro ADME assays manually or using automated liquid handling system for completion in a fast-paced environment, while managing multiple projects to meet the timelines  

• Perform Bioanalytical method development and quantification using UPLC-MS/MS.  

• Actively participate in scientific discussion to resolve arising issues as well as critically analyse and interpret the data to design next steps.  

• Work closely with project managers and senior management to complete the assigned work in the anticipated time frame.  

• Provide expert scientific support for the wider company for ADME studies. 

• Keep up to date with scientific literature advances, developments, and regulatory guidelines in the area of ADME and inform the team of relevant developments. 

• Provide practical scientific guidance to others, collaborating across functions to meet project goals, and regularly presenting findings. 

• Promote cross functional collaboration with other Principal Scientists and to provide opportunity for team members to contribute to these collaborations. 

• Provide expert scientific support for the wider company for drug metabolism studies. 

People

• Coach, mentor and line manage other members of the team by effective use of Evotalks meetings, regular 1to1 discussions and ad hoc interactions. 

• Assist team members in generating development plans and to review and provide support to team members in executing these plans. 

• Assist the VP in generating succession plans for the team. 

Business

• Responsible for managing and coordinating multiple projects/activities within the group with a results-driven approach. 

• Proactively take the initiative to improve group processes and make efficiency gains in assays. 

• Encourage a continuous improvement culture and to manage projects to completion. 

• Participate in internal and external partner meetings as and when required. 

Self

• Ensure appropriate Health and Safety procedures are always followed in the workplace. 

• Participate in all mandatory training required to perform effectively in job role. 

• Ensure that your personal training record is up to date and that any gaps are discussed with your supervisor. 

• Actively participate in Evotalks and agree on personal targets and expectations with supervisor. 

Who You Are:

• Requires a PhD  (5+ years experience) in biology, chemistry, pharmaceutical sciences, or an equivalent combination of education, training and experience from which comparable knowledge, skills and abilities have been attained.  The title will be commensurate with experience.   
• Excellent writing and verbal communication skills that enable the candidate to function effectively on a collaborative multi-disciplinary work team. 
• Very strong organization skills and attention to detail will be essential, especially for performing the in-vitro assays for this job.
• Detailed knowledge of bioanalysis within ADME/DMPK
• Hands on experience of bioanalytical method development and quantification of small molecules and peptides in complex matrices
• Strong understanding of UPLC-MS/MS systems
• Troubleshooting skills in assays and instrumentation
• An understanding of pharmacokinetic parameter determination and interpretation
• Experience locating and applying information in the scientific literature

The base pay range for this position at commencement of employment is expected to be $113,900 to $154,100. This is a salaried exempt position. Base salary offered may vary depending on the individual’s skills, experience and competitive market value. Additional total rewards include discretionary annual bonus, comprehensive benefits to include Medical, Dental and Vision, short-term and long-term disability, company paid basic life insurance, 401k company match, flexible work, generous paid time off and paid holiday, wellness and transportation benefits.

Evotec (US) Inc. is an Equal Opportunity Employer.  All qualified applicants will receive consideration for employment without regard to race, gender, age, disability, genetic information, gender expression, gender identity, national origin, religion, sexual orientation, or veteran status.