Senior Scientist II, Cell Line Development

Just – Evotec Biologics is seeking a highly motivated and creative senior-level cell line development (CLD) scientist who is seeking a significant opportunity to improve worldwide access to biotherapeutics. This position will be responsible for driving scientific innovation, executing cell line development for client and partner programs, and leading and mentoring a small team of junior level scientists. Deep experience in mammalian cell culture (CHO experience preferred), molecular biology, and stable transgene expression are required. Experience in genome editing, next-gen sequencing, automation/liquid handling, antibody structure, computational biology, and biotherapeutic process development (PD) are desired. The successful candidate must also possess strong skills in written and verbal communication, leadership, and collaboration; a desire to learn new scientific concepts and domains; and an ability to work directly with scientific staff across multiple disciplines. A proven track record in cell line development, technology development, familiarity with analytical characterization, and a working knowledge of CMC manufacturing is required. Experience with early and late-stage regulatory filings and regulatory interactions is highly desired.

Responsibilities:

• Execute cell line development activities, including creating stable cell lines, single-cell cloning, and preparing CLD-related documents that support IND filing
• Manage, train, and provide scientific mentorship to junior staff to work innovatively and collaboratively
• Optimize strategies, and workflows that increase efficiency and de-risk projects
• Lead efforts to identify, evaluate and champion new CLD technologies to support the mission of low cost biotherapeutics
• CMC Lead and/or functional area lead for complex client or technology projects
• Drive scientific and technological innovation in CHO cell engineering
• Evaluate and implement novel technologies to improve CLD platform
• Support successful MCB and WCB manufacturing for client projects
• Contributing or primary author of regulatory documents, patents, external publications, presentations/posters. Represent Just at external meetings and conferences

Qualifications:

• PhD in a related scientific area with 5+ years of relevant experience; or BS with 10+ years of relevant experience
• Strong SME in cellular and molecular biology techniques to create stable cell lines suitable for protein therapeutics
• Experience with expression construct design for cell lines expressing large molecules, such as mAbs, fusion proteins, and bispecifics
• Expertise in cell line development for protein therapeutics including experience with multiple mammalian cell lines
• Proficiency creating novel expression vectors to obtain highly productive cell lines that express material to meet process development product quality targets
• Experience in cell line development for commercialization of novel biologics and biosimilars, including experience designing cell lines to match innovator PQA/CQA
• Experience utilizing high throughput automation and data systems
• Excellent written and verbal communication skills, with expertise communicating effectively over teleconference and web-based meetings. Comfort with scientific presentations to all types of audiences, including senior leadership and executive
• Passionate about development of new technology with strong drive toward innovation in areas of genome engineering, including CRISPR-based methods and next-gen sequencing

The base pay range for this position at commencement of employment is expected to be $125,000 to $140,000;  Base salary offered may vary depending on individual’s skills, experience and competitive market value. Additional total rewards include discretionary annual bonus, comprehensive benefits to include Medical, Dental and Vision, short-term and long-term disability, company paid basic life insurance, 401k company match, flexible work, generous paid time off and paid holiday, wellness and transportation benefits.

Evotec (US) Inc. is an Equal Opportunity Employer.  All qualified applicants will receive consideration for employment without regard to race, gender, age, disability, genetic information, gender expression, gender identity, national origin, religion, sexual orientation, or veteran status.